A rapid, specific, accurate, precise and robust reverse phase high performance liquid chromatographic method was developed for the estimation of paliperidone in tablet dosage form. The method was carried out on bondapack column (3.9 mm x 300 mm) column. Mobile phase composed of methanol and buffer (0.5% ammonium dihydrogen phosphate adjusted to pH 3 by using orthophosphoric acid) in the ratio of 75:25v/v, used at a flow rate of 1 ml/min. Detection was carried out at 235 nm. Paliperidone was eluted at the retention time of 3.4±0.1 min. The Linearity was found to be in the range 1 – 1000 µg/ml (r2 = 0.998). Both precision and accuracy were determined and as the % RSD testifies, the method was accurate and precise. The results obtained in this study proved that the developed method was reliable, precise, robust and accurate.
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